Ann: Quarterly Update / Appendix 4C, page-3

In anticipation of increased demand, several scaled-up production runs of 100mwere completed at Operon during the quarter (up from 25m) to allow manufacturing scalability to maximum capacity when required. We have worked in partnership with Operon to identify several steps that can be optimised during the manufacturing process to secure maximum output. We are now working with Operon to implement these steps to ensure scale-up manufacturing processes are optimal for maximum capacity production runs. Separately, we continued quality testing across product batches with actual samples during the quarter.