IMU 1.16% 4.4¢ imugene limited

bendigo whoosh building

  1. 4,996 Posts.
    As part of the new research program, Dr Sheppard will

    use the new synthetically synthesized gene to make

    updated versions of the single gene (HA gene) broiler

    vaccine at the La Trobe University laboratory. Recent

    Publications on Avian Influenza support Imugene’s

    research Recent publications in scientific journals in

    which the HA antigen has been successfully inserted

    into adenoviruses to create an effective vaccine

    support the research approach Imugene has

    undertaken. The vaccines in publications to date still

    require at least two injections and take at least 21

    days to provide immunity. This results in protection for

    only half the average life of a broiler (meat producing)

    bird. These parameters severely limit the commercial

    viability of the vaccines to date. The adenoviruses

    used have all been human strains or avian strains that

    are classed as "replication defective" This means they

    are unable to multiply in the birds and therefore require

    higher doses. In contrast, the Imugene vaccine

    candidates are based on Imugene’s patented avian

    adenovirus that is replication competent (able to

    multiply after administration). This methodology has the

    following advantages: 1. Suitable for oral or in ovo (into

    the egg) administration 2. Lower dose (often 1/1000th

    of that required for replication defective vectors) 3.

    Possibility of single dose 4. Allows differentiation of

    vaccinated from infected birds


    ---------------------------------------------------

    Dr Sheppard is now also developing a vaccine for the

    broiler poultry market using a different technique than

    that being undertaken at CSIRO. This technique utilises


    genes that were selected and synthesized in Europe.

    These genes have now arrived in Australia and

    construction of the vaccine candidates for testing is

    progressing well.

 
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