As part of the new research program, Dr Sheppard will
use the new synthetically synthesized gene to make
updated versions of the single gene (HA gene) broiler
vaccine at the La Trobe University laboratory. Recent
Publications on Avian Influenza support Imugene’s
research Recent publications in scientific journals in
which the HA antigen has been successfully inserted
into adenoviruses to create an effective vaccine
support the research approach Imugene has
undertaken. The vaccines in publications to date still
require at least two injections and take at least 21
days to provide immunity. This results in protection for
only half the average life of a broiler (meat producing)
bird. These parameters severely limit the commercial
viability of the vaccines to date. The adenoviruses
used have all been human strains or avian strains that
are classed as "replication defective" This means they
are unable to multiply in the birds and therefore require
higher doses. In contrast, the Imugene vaccine
candidates are based on Imugene’s patented avian
adenovirus that is replication competent (able to
multiply after administration). This methodology has the
following advantages: 1. Suitable for oral or in ovo (into
the egg) administration 2. Lower dose (often 1/1000th
of that required for replication defective vectors) 3.
Possibility of single dose 4. Allows differentiation of
vaccinated from infected birds
---------------------------------------------------
Dr Sheppard is now also developing a vaccine for the
broiler poultry market using a different technique than
that being undertaken at CSIRO. This technique utilises
genes that were selected and synthesized in Europe.
These genes have now arrived in Australia and
construction of the vaccine candidates for testing is
progressing well.
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