Media Thread, page-60

A failed drug trial in non-small lung Ca & another one with pre-treatment & combo therapy trial. The comment of Novel treatment beyond targeting T-cells was interesting:

“The study, called EMERGE, was testing three dose levels of Jounce’s drug, vopratelimab, with Opdivo in 59 patients who had already tried PD-1 or PD-L1 inhibitors like Bristol Myers Squibb’s Opdivo or Merck’s Keytruda. Yervoy works by targeting CTLA-4, a receptor found on T cells that acts as a “brake” on the immune system. Adding vopratelimab to the mix, Jounce thought, would activate ICOS, a different protein on the T cells, to boost their proliferation and expansion after Yervoy released the immune brake. But data from 50 evaluable patients said otherwise.”

https://www.fiercebiotech.com/biotech/jounce-sinks-as-it-ditches-phase-2-yervoy-combo-trial

“The PD-(L)1 experienced or resistant population continues to prove difficult to treat. To bring necessary benefit to these patients it is becoming clearer that novel approaches beyond T cells may be needed as part of the solution,” Jounce CEO Richard Murray, Ph.D., said in the statement.