Firebrick Pharma (ASX code: FRE) is an Australian pharmaceutical innovator established in 2012 with the mission to develop a nasal spray treatment for the common cold using the well-established antiseptic agent, povidone-iodine (PVP-I).
By 2020, the company had successfully developed the nasal spray product (called “Nasodine® Nasal Spray”), including completing Phase 1, Phase 2 and Phase 3 human clinical trials in support of its use as a treatment for the common cold. During the COVID pandemic, Firebrick also completed two Phase 2 human clinical trials demonstrating that Nasodine eliminated the SARS-CoV-2 virus and stopped viral shedding from COVID-19 patients.
Firebrick has granted international patents on the use of intranasal PVP-I as a treatment and preventative for the common cold, and as method for reducing the viral load of SARS-CoV-2. A pharmaceutical composition patent was also filed in 2021 protecting the Nasodine formulation. In 2022, Firebrick listed on the ASX under the code FRE.
In 2024, Firebrick successfully completed commercial scale manufacturing of Nasodine Nasal Spray and subsequently launched the product in USA, Singapore and Fiji, with plans to launch into other markets in 2025 and 2026. Firebrick has also completed development of several new products (undisclosed), which are expected to be introduced by 2026.
Firebrick has successfully transitioned from an R&D focused life sciences company to an emerging commercial enterprise that is at the start of an exciting journey to see the profitable commercialisation of its product pipeline. Its commercial activities are spearheaded by Nasodine Nasal Spray, a breakthrough product that meets the growing global need for protection against airborne germs, whether the common cold or the next pandemic.
Website: https://firebrickpharma.com/
Investor Update - Sep 2024: https://hotcopper.com.au/threads/ann-firebrick-investor-update.8222646/page-4?post_id=75931646
Investor Webinar - Feb 2025: https://hotcopper.com.au/threads/webinar-invest-in-the-future-of-healthcare-%E2%80%93-firebrick-pharma%E2%80%99s-investor-webinar.8468717/?post_id=78057533
Background and technical
Peter Molloy’s history and how Betadine was the inspiration for Firebrick
Povidone-iodine (PVP-I) and why we started Firebrick
Targeted antivirals and vaccines for the common cold are not the answer
- https://hotcopper.com.au/threads/firebrick-pharma-company-rep-account.6725939/page-6?post_id=61349796
- https://hotcopper.com.au/threads/chinese-covid-inhaler.6948003/page-2?post_id=63593396
Why can’t you just put Betadine® solution in a nasal spray?
- https://hotcopper.com.au/threads/nasal-spray.6526304/page-82?post_id=61433276
- https://hotcopper.com.au/threads/nasodine-an-amazing-opportunity-going-forward.8384958/page-21?post_id=77545522
How Nasodine is different to barrier nasal sprays classified as medical devices:
- https://hotcopper.com.au/threads/fyi.6819487/?post_id=62325542
- https://hotcopper.com.au/threads/beware-nasal-sprays-registered-as-medical-devices.7064025/?post_id=64546332
- https://hotcopper.com.au/threads/mystery-disease-outbreak-in-china-2025.8391332/page-6?post_id=77353832
How Nasodine is different to “Betadine” Cold Defence nasal spray
- https://hotcopper.com.au/threads/ann-nasodine-nasal-spray-launch-in-the-usa.7953932/page-73?post_id=74280089
- https://hotcopper.com.au/threads/ann-successful-nasodine-patent-defense-in-singapore.8401341/page-9?post_id=77415266
Where to buy Nasodine: nasodine-sg.com
- https://hotcopper.com.au/threads/price-prediction-10-cents-in-march.8432673/page-38?post_id=78680815
Article: How venture capitalists shaped the modern biotech
Strategy and mission
Firebrick’s global mission and strategy
- https://hotcopper.com.au/threads/ann-appendix-4e-and-annual-report-30-june-2024.8180988/page-2?post_id=75458781
- https://hotcopper.com.au/threads/biggest-day-in-a-while-cheers-to-the-holders.8194260/page-6?post_id=75641671
- https://hotcopper.com.au/threads/biggest-day-in-a-while-cheers-to-the-holders.8194260/page-9?post_id=75657906
- https://hotcopper.com.au/threads/ann-firebrick-investor-update.8222646/page-4?post_id=75931646
How the Firebrick business model is different to most biotechs
Strategy to market Nasodine as a nasal antiseptic
- https://hotcopper.com.au/threads/ann-update-on-nasodine-trial-and-forward-plans.7612985/page-11?post_id=70148548
- https://hotcopper.com.au/threads/ann-firebrick-investor-update.7699477/page-15?post_id=70917379
- https://hotcopper.com.au/threads/christmas-wish-of-releasing-positive-announcement-before-christmas.7744546/page-17?post_id=71521995
- https://hotcopper.com.au/threads/ann-nasodine-composition-patent-granted-in-south-africa.8015553/page-6?post_id=74020252
Nasodine Nasal Spray opportunity
Nasodine effectiveness reviews on HotCopper
- https://hotcopper.com.au/threads/ann-nasodine-nasal-spray-launch-in-the-usa.7953932/page-68?post_id=73963885
- https://hotcopper.com.au/threads/ann-new-agreement-allows-nasodine-launch-in-philippines.8148417/page-2?post_id=75214449
- https://hotcopper.com.au/threads/ann-new-agreement-allows-nasodine-launch-in-philippines.8148417/page-11?post_id=75305192
Nasodine product details: pack, dose, shelf-life, safety, nasal microbiome
How to use Nasodine
Does Nasodine affect the nasal microbiome
Doctors want Nasodine available
- https://hotcopper.com.au/threads/ann-firebrick-raises-1-million-via-placement.7358626/page-24?post_id=67883536
- https://hotcopper.com.au/threads/ann-nasodine-to-be-launched-in-fiji-and-south-pacific.8441268/page-4?post_id=77817331
How COVID-19 impacted Nasodine
- https://hotcopper.com.au/threads/ann-successful-nasodine-patent-defense-in-singapore.8401341/page-11?post_id=77424937
- https://hotcopper.com.au/threads/nasodine-an-amazing-opportunity-going-forward.8384958/page-25?post_id=77563896
- https://hotcopper.com.au/threads/price-prediction-10-cents-in-march.8432673/page-43?post_id=78777988
Nasodine for front line defence in future pandemics
Sinusitis and hay fever
New products
Nasodine patents
- https://hotcopper.com.au/threads/ann-nasodine-covid-19-patent-allowed-in-us.7885003/
- https://hotcopper.com.au/threads/ann-successful-nasodine-patent-defense-in-singapore.8401341/page-5?post_id=77399471
- https://hotcopper.com.au/threads/ann-successful-nasodine-patent-defense-in-singapore.8401341/page-11?post_id=77424937
Nasodine sales development and market potential
- https://hotcopper.com.au/threads/all-these-ann-and-still-no-movement.8295141/page-3?post_id=76417355
- https://hotcopper.com.au/threads/monthly-check-in.8361777/page-8?post_id=77082147
- https://hotcopper.com.au/threads/monthly-check-in.8361777/page-21?post_id=77184699
- https://hotcopper.com.au/threads/mystery-disease-outbreak-in-china-2025.8391332/page-9?post_id=77355741
- https://hotcopper.com.au/threads/price-prediction-10-cents-in-march.8432673/page-26?post_id=78276821
- https://hotcopper.com.au/threads/price-prediction-10-cents-in-march.8432673/page-43?post_id=78777988
- https://hotcopper.com.au/threads/ann-march-2025-quarterly-activity-report-appendix-4c.8542848/?post_id=78709908
Clinical trials
COVID-19 Phase 2 trial
- https://hotcopper.com.au/threads/ann-nasodine-covid-19-trial-concludes-recruitment.7313917/?get_post=true&direction=previous
- https://hotcopper.com.au/threads/ann-nasodine-covid-19-trial-concludes-recruitment.7313917/page-3?post_id=67106431
- https://hotcopper.com.au/threads/ann-firebrick-covid-19-trial-achieves-primary-endpoint.7512850/
- https://hotcopper.com.au/threads/ann-firebrick-covid-19-trial-achieves-primary-endpoint.7512850/page-6?post_id=69194815
- https://hotcopper.com.au/threads/ann-nasodine-phase-2-covid-19-trial-results-published.7929071/
Second common cold Phase 3 trial
- https://hotcopper.com.au/threads/ann-firebrick-phase-3-trial-closes-with-500-subjects.7517032/
- https://hotcopper.com.au/threads/ann-phase-3-common-cold-trial-results.7578873/page-67?post_id=69873459
- https://hotcopper.com.au/threads/ann-firebrick-investor-update.7699477/page-15?post_id=70917379
Does FRE plan to do another clinical trial in the future?
TGA-related
S60 appeal
- https://hotcopper.com.au/threads/ann-firebrick-starts-phase-3-common-cold-trial-of-nasodine.6725998/page-4?post_id=61201167
- https://hotcopper.com.au/threads/ann-outcome-of-s60-appeal-for-nasodine-and-next-steps.6833587/
- https://hotcopper.com.au/threads/fre-is-one-to-watch.6647761/page-29?post_id=62435949
AAT Appeal
- https://hotcopper.com.au/threads/fre-is-one-to-watch.6647761/page-29?post_id=62435949
- https://hotcopper.com.au/threads/ann-nasodine-appeal-timetable-agreed-at-aat-conference.7125175/?get_post=true&direction=previous
- https://hotcopper.com.au/threads/ann-update-on-nasodine-aat-appeal-timetable.7405030/page-4?post_id=68026969
Market entries
Launch in the USA, market strategy
- https://hotcopper.com.au/threads/ann-nasodine-nasal-spray-launch-in-the-usa.7953932/?post_id=73379168
- https://hotcopper.com.au/threads/ann-nasodine-nasal-spray-launch-in-the-usa.7953932/
- https://hotcopper.com.au/threads/ann-firebrick-raises-1-million-via-placement.7358626/page-32?post_id=68538419
- https://hotcopper.com.au/threads/global-nasal-spray-market-expected-to-reach-us-40-59-billion-by-2033.8442192/page-2?post_id=77838927
- https://hotcopper.com.au/threads/price-prediction-10-cents-in-march.8432673/page-46?post_id=78787685
Launch in Singapore
- https://hotcopper.com.au/threads/nasodine-singapore-update.8087679/?post_id=74654892
- https://hotcopper.com.au/threads/nasodine-singapore-update.8087679/page-2?post_id=74700471
- https://hotcopper.com.au/threads/ann-agreement-signed-to-market-nasodine-to-hcps-in-singapore.8290677/page-3?post_id=76392239
- https://hotcopper.com.au/threads/nasodine-wins-guardian-award-in-singapore.8589001/?post_id=79105600
Launch in Fiji and South Pacific
Future launch in the Philippines
- https://hotcopper.com.au/threads/ann-new-agreement-allows-nasodine-launch-in-philippines.8148417/?post_id=75213237
- https://hotcopper.com.au/threads/ann-new-agreement-allows-nasodine-launch-in-philippines.8148417/page-7?post_id=75217073
- https://hotcopper.com.au/threads/ann-new-agreement-allows-nasodine-launch-in-philippines.8148417/page-9?post_id=75222293
- https://hotcopper.com.au/threads/ann-new-agreement-allows-nasodine-launch-in-philippines.8148417/page-10?post_id=75225099
