http://www.cureffi.org/2013/03/03/prospects-for-gene-therapy-of-prion-diseases/
The author discusses RNAi, including shRNA, and viral vector delivery. Interesting comments near the end:
"here’s why I’m an optimist about gene therapy: there is almost nothing disease-specific about these problems of safe and effective delivery. The biggest remaining hurdles to gene therapy today are universal enough that progress in one disease means progress for all"
"If we can solve a few fundamental problems of delivery, we’ll have unlocked the treatment for virtually every genetic disease – and a pile of non-genetic diseases too. This should be among our top priorities as a species"
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