speaking of gradaiis

These guys are certainly going a great job in developing RNAi. I wish they would take a licence form us. This is their latest paper on pancreatic cancer.

Vertically integrated translational studies of PDX1 as a therapeutic target for pancreatic cancer via a novel bifunctional RNAi platform

J Wu, S Liu, J Yu, G Zhou, D Rao, C M Jay, P Kumar, R Sanchez, N Templeton, N Senzer, P Maples, J Nemunaitis and F C Brunicardi

Abstract
RNA interference (RNAi) represents a powerful, new tool for scientific investigation as well as a promising new form of targeted gene therapy, with applications currently in clinical trials. Bifunctional short hairpin RNA (shRNA) are synthetic RNAi molecules, engineered to utilize multiple endogenous RNAi pathways to specifically silence target genes. Pancreatic and duodenal homeobox 1 (PDX1) is a key regulator of pancreatic development, ß-cell differentiation, normal ß-cell function and pancreatic cancer. Our aim is to review the process of identifying PDX1 as a specific, potential RNAi target in pancreatic cancer, as well as the underlying mechanisms and various forms of RNAi, with subsequent testing and development of PDX1-targeted bifunctional shRNA therapy.

http://www.nature.com/cgt/journal/vaop/ncurrent/full/cgt201384a.html