But the very wide 95% confidence interval indicates this is a very unreliable estimate. Somewhere between 0.02 (very positive) and 1.44 (a detrimental effect for Cvac)
In this case 95% CI with See SthOz ~ Lower Limit 0.02 (Very +ve) Upper Limit 1.44 (Very poor effect)....With a P=0.07 so its closer to the lower limit very positive
To work out the statistic the used the Pearsons Correlation
The computation of a confidence interval on the population value of Pearson's correlation (ρ) is complicated by the fact that the sampling distribution of r is not normally distributed. The solution lies with Fisher's z' transformation described in the section on the sampling distribution of Pearson's r. The steps in computing a confidence interval for ρ are:
Convert r to z'
Compute a confidence interval in terms of z'
Convert the confidence interval back to r.
Let's take the data from the case study Animal Research as an example. In this study, students were asked to rate the degree to which they thought animal research is wrong and the degree to which they thought it is necessary. As you might have expected, there was a negative relationship between these two variables: the more that students thought animal research is wrong, the less they thought it is necessary. The correlation based on 34 observations is -0.654. The problem is to compute a 95% confidence interval on ρ based on this r of -0.654.
The conversion of r to z' can be done using a calculator. This calculator shows that the z' associated with an r of -0.654 is -0.78.
The sampling distribution of z' is approximately normally distributed and has a standard error of
For this example, N = 34 and therefore the standard error is 0.180. The Z for a 95% confidence interval (Z.95) is 1.96, as can be found using the normal distribution calculator (setting the shaded area to .95 and clicking on the "Between" button). The confidence interval is therefore computed as:
Lower limit = -0.775 - (1.96)(0.18) = -1.13
Upper limit = -0.775 + (1.96)(0.18) = -0.43
The final step is to convert the endpoints of the interval back to r using a calculator. The r associated with a z' of -1.13 is -0.81 and the r associated with a z' of -0.43 is -0.40. Therefore, the population correlation (ρ) is likely to be between -0.81 and -0.40. The 95% confidence interval is:
-0.81 ≤ ρ ≤ -0.40
To calculate the 99% confidence interval, you use the Z for a 99% confidence interval of 2.58 as follows:
Lower limit = -0.775 - (2.58)(0.18) = -1.24
Upper limit = -0.775 + (2.58)(0.18) = -0.32
Converting back to r, the confidence interval is:
-0.84 ≤ ρ ≤ -0.31
Naturally, the 99% confidence interval is wider than the 95% confidence interval.
For my previous post On Survival
1 The ratio of survival in one group as compared with survival in another. A hazard ratio of 0.17 means that the risk of death at a specific timepoint is reduced by 83% for patients receiving CVac compared to those receiving SOC.
Source: http://www.primabiomed.com.au/investor/pdf/2015/19_05_15_announcement.pdf
(20min delay)