Ann: Appendix 3B-RAP.AX, page-13

Hi Fumes,

I am a pretty polite sort of guy, but your assertion that the US trials were due 3-6 months ago is just just straw brained. Check their schedule. They were due end of 2nd quarter.

Additionally, the results required for the FDA submission are a composite of both Aussie and US results. The FDA requires some but not ALL trials to be done in the US. We are well on the way and I have no doubt that we are right on target.

Don't under estimate that a sizeable US hospital(s) will give an accelerated thru put of patients that will not just get us well on schedule, but possible ahead of schedule with the additional benefit of accelerating portfolios of other diseases.

CT

PS I have a spare clown suit for you if you wish.