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23/09/16

23:41

Post #: 19391723
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Originally posted by skint ↑

Yes M123, I am not saying an accelerated approval will happen, just that in my view it should. If you are looking for a competing product with very deep pockets, perhaps look at Roche. They have their gene silencing drug IONIS-Htt is currently in a 1/2a trial. They silence the gene, not by modulating the gene directly, but by stopping the RNA signal given off by the gene. As far as I know once the Htt protein goes prion, it does not require a RNA signal to reproduce. Happy to be contradicted there if that is not correct. That being true, then the RNA drug would be most effective in prodromal and very early stage, which is probably where PBT2 would be most effective.

Before this PCH Prana was way in front.

US biotech Omeros also has a Huntington's candidate and is also in a partial clinical hold. Based on rodent results, as has been discussed here before.

"OMS824 is in a Phase 2 clinical program for the treatment of Huntington’s disease and a Phase 2 clinical program evaluating OMS824 for the treatment of schizophrenia. Clinical trials in our Huntington’s program are currently subject to dosing limitations. The dosing limitations may potentially be removed pending generation, submission and FDA review of additional information. We are conducting nonclinical studies to generate additional data for further discussion with the FDA regarding the dosing limitations and are currently preparing for a re-designed Phase 2 clinical trial in patients with Huntington’s disease."

Sound familiar.

Roche dodged the FDA and is running their trial in EU and I think Aus

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" Before this PCH Prana was way in front."

kadaicher - You sound very confident in this assertion. Go back as far as you like and give us any evidence that you can find to support your opinion that Prana was ever "way out in front".

PBT Price at posting: 10.5¢ Sentiment: None Disclosure: Not Held
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