X So you question results in humans. Thanks
Now do you remember in 2013 that the Huntington's Study Group introduced a new questionnaire for the purpose of evaluating clinical relevance for trial patients. Called HD-PROP. It was presented at the 17th annual Congress for Parkinson's Disease and Movement Disorders. I think Reach2HD was the first trial where it was applied. The results were pretty spectacular I thought with 90% of all improvers on PBT2. over the entire trial population. Not a sub group. 90%. Considering there are no drugs to modify cognition in HD, that is a very compelling result, IMO to go with the stat sig gains seen in TMT-B..
Those blue dates are live links. Read them. The relevance of those studies has not diminished, in fact with the human clinical results in, they have become more important. You see it is very difficult to bridge that gulf between mouse model results and human results, but so far PBT2 has done that.
The test powered for cognition in AD is yet to be done.
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