things I've learnt over the last 14 months, page-20

You have removed a word from its context and used it to paint a broad picture of failure. You have made a thread with it in the title to pass the brush over MSB's prospective partner. You have used the same word to appeal to investors' fears. Which of us doesn't have a stock with so much 'potential' languishing in our bottom drawer? Your writing shows awareness of readers' psychology and techniques to make weak material appear strong. You certainly have potential as a professional writer, if you are not one already.

The word 'potential' refers to a clinical trial involving children of which the outcome is not known. What other word would you expect a doctor to use? Potential is commonly used in medicine because the therapy may not work for every person. What therapy does? MSB has an actual product for aGVHD being fast tracked. While it's a tiny market, there are implications for other steroid refractory conditions.

I don't have a science background but I always thought the heart would be difficult, being a pressure vessel with moving parts. But hasn't differentiation and repair been observed in a variety of animal models? I thought the John Hopkins pigs study was impressive. We're at the early stages of humans trials, but hasn't improved function and quality of life already been observed? I know there's competition in the area of mesenchymal stem cells in CHF but my pick is MSB because the stem cells are allogeneic. I think time in cardiac events is important.

I infer from your writing that MSB's inability so far to find a partner is somehow a reflection of its quality. You're talking about introducing new technology into a very conservative environment. It's also disruptive technology. Mesenchymal stem cells have the potential to impact highly lucrative revenue from biologics. After Teva left, I read the article where Alex Waislitz said the company should concentrate on their CHF candidate. I thought a lot about it. I think he's right. I also think LBP is huge market and there doesn't appear to be anything else effective.

Imo there's no guarantee MSB will make it, but if it doesn't, it won't be because the science is flawed.

You're right to point out the risks of investing at this stage.

BTW congrats on your tiny red heart. It certainly makes mine flutter every time it pops up on this forum.