Ann: Patrys and WEHI Awarded Grant, page-21

BarrelSitter, That's precisely why the collaboration with the Walter Eliza Hall Institute announcement is so interesting and "potentially" a critical break through. The very simplicity of the logic is very captivating.

"The work will couple Patrys’ PAT-DX1 with the Institute’s 7D10 to generate a bi-specific antibody called 7D10-PAT-DX1. 7D10 protein interacts with the Bak protein inside cells to cause cell killing but is unable to pierce a cancer cell’s outer membrane and bind to its targets by itself. PAT-DX1 is a novel antibody that can enter and kill cancer cells harboring defective DNA repair mechanism. Combining these technologies by the generation of a bi-specific 7D10-PAT-DX1 antibody will result in a novel antibody that will be able to enter a cell, bind to its targets and act to help circumvent 2 survival pathways typically employed by cancer. An intra-vital microscopy technique that Associate Professor Hawkins uses will allow following up of the cancer disease to see how the disease is affected when 7D10-PAT-DX1 therapy is introduced. “Patrys has an established relationship with Dr Kluck and is looking forward to expanding that and building a new relationship with Associate Professor Hawkins. The collaboration should provide data regarding the potential effectiveness of 7D10-PAT-DX1 to kill cancer cells,” said Dr James Campbell."