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PROGEN--PGL.

Website: http://www.progen.com.au/

BigChart: http://bigcharts.marketwatch.com/javachart/javachart.asp?symb=au%3APGL&time=&freq=

Shares: 33.9 mill; price $1.63. Options: 4.2 mill to convert to shares by payment of $2.50 on 31 May 2005; code PGLO. Another 0.92 mill unlisted options. Cash: $16 mill. on Nov. 11, 2003.

PGL also manufactures drugs for other companies.

1. DRUG PI-88
Oct 3, 2000: Commences New Human Trials:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=136866

Nov. 23, 2000: US Patent granted for Anti-cancer/Anti-thrombotic Drug:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=137957

Febr.2, 2001:Clears first clinical trial hurdle with concl of PI Phase 1b--Preparing for Phase II:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=138995

March 26, 2001: Launch of inflammatory disease research program:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=139826

April 11, 2001: Alliance Partner to Conduct Indep. Phase 1b Clinical Trial:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=140084

June 6: US Patent granted for gene encoding Heparanase enzyme:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=140838

Aug 2, 2001: 1st US Clinical trial with anti-cancer drug PI-88 commences (Advanced Melanoma):
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=141718

Aug. 13, 2001: ComplementaryUS Patient Granted for Progen`s Lead Drug PI-88:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=141893

Nov. 20, 2001: PI-88 a potential leukaemia drug:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=143774

Jan. 22, 2002: Australia, start of Phase II clinical trial (Mult. Myeloma)
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=144843

June 5, 2002: Combination trial ( PI-88 + Taxotere), Phase I, to start in the US in July (Melanoma):
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=146912

July 9, 2002: PGL has reached a significant milestone in its program to develop novel drugs to inhibit the enzyme heparanase.
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=147368

Nov. 25, 2002: Encouraging Human Trial Data from Progen`s PI-88 (Prel. data from Phase I/II , Melanoma and Renal-cell Carcinoma) presented in the US:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=149993

May 7, 2003: Additional Results Support Cancer Trials Strategy-Three clinical trials investigating the therapeutic effect of PI-88 on solid tumours including melanoma, lung and liver cancers are underway:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=152738

IMPORTANT: June 4, 2003: Recent International Clinical Results Validate PGL's Strategy:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=153158

July 8, 2003: Achieves efficacy endpoint in Phase II Multiple Myeloma Trial (Australia):
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=153679

Sept. 30, 2003: Progen's PI-88 Presented at US Antiangiogenesis Conference:

“Progen’s lead drug candidate PI-88 also targets VEGF along with other cancer-related growth factors such as b-FGF as well as heparanase, a degrading enzyme associated with angiogenesis and metastasis.”
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=155338

Oct. 29, 2003: Granted Anti-Angiogenesis Antibody Patent:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=156132

Jan. 21, 2004: PI-88 Melanoma Phase II trial commenced-Joint Australia and US.
" Rob Don, Progen’s VP of R&D commented “PI-88 has been well tolerated by patients in the Phase I trial.

We have also seen positive signs that PI-88 has retarded tumor growth in over 40% of the melanoma patients for periods lasting up to 30 months.

This Phase II clinical trial in advanced melanoma patients is the first of three new PI-88 Phase II trials that will be initiated in the near future":

http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=157916

"Melanoma is the number one cause of cancer death in women aged 25 to 30. For more information on melanoma please visit: http://www.nci.nih.gov/cancer_information/cancer_type/melanoma


2. DRUG PI-166:
Sept 18, 2002: PI-166 added to Development Pipeline:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=148587

Jan. 13, 2003: Commences Human Liver Cancer Phase 1b Trial with PI-166- St. George, Sydney.
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=150786

3. OTHER:
Dec 17, 2001: US Funding for Progen (Malaria studies):
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=144238

June 7, 2002: Second Provisional Specification:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=146958

Aug. 19, 2002: Media Release: Manufacturing Alliance with CSIRO:
http://stocknessmonster.com/news-item?S=PGL&E=ASX&N=148001


Gerry Stolwyk
Readers, please do your own research and you decide if and when to buy, hold or sell any stocks.