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clock Created with Sketch. 06/03/20
15:14
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Originally posted by RaceOncology:
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OK I had a chance to read the paper (pre-print) over lunch. I should preface that I am not an expert in molecular modelling and docking, but I do have some understanding of the area. If we have some real experts here I would certainly love to hear from you.What does the paper show? This is a computer modelling study. The author took the crystal structure (3D model) of the COVID-19 protease (this is one of the essential parts of the coronavirus, without a functional protease the virus can’t replicate) and did a docking study (I will explain what docking is below) with 3639 “approved” drug structures to see what was calculated to bind to the proteases. He found that some of the drugs appeared to bind tightly to the proteases and potentially inactivate it (i.e. kill the virus). Most of the drugs were known anti-virals for other viruses, but Bisantrene was also on the list at number 13 out of 3639.What is Docking? What does this mean for Bisantrene? What does this mean for RAC? What are we going to do?
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Hi Daniel,
Last edited by
bkng :
06/03/20
(20min delay)