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Ann: Kazia paxalisib Phase II interim data, page-13

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Jazzasax

3,137 Posts.

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07/04/20

15:05

Post #: 43930369
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Originally posted by onesurfed ↑

BB- I think I was wrong about it being Pax on it's own. "This phase 2 study comprises an open-label, multicenter, dose-escalation and expansion study to assess the safety, tolerability, RP2D, PK and clinical activity of GDC 0084 in patients with newly-diagnosed GBM with unmethylated MGMT promoter status as adjuvant therapy following surgical resection and initial chemoradiation with TMZ."

So patients have been treated with TMZ. Still, results in the unmethylated MGMT-promoter group are superior to TMZ in the methylated MGMT-promoter group, and that's the only group that TMZ works on. Pax will treat 65% of patients better than TMZ treats 35% of the patients.

We've yet to see Pax vs. methylated MGMT-promoter group, unless I'm missing something. My shoddy memory and research leaves a great opportunity for others!I

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Hi @onesurfed, I believe the AGILE trial will include testing the methylated group as well as unmethylated...but my memory may be worse than yours!!

KZA Price at posting: 44.5¢ Sentiment: Buy Disclosure: Held
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