Hi @sisyphean ! I take it you probably were sound asleep in bed last night as the war of the words raged on between the MSB crack squad and the FDA missive?
The MOA is actually happening. Its evidenced by the cell-surface markers. That's what makes out cells SO potent. The expression of TNFR1 (that then causes the NF-kappa beta signalling and the downstream secretion of the the immunomodulatory cytokines) and the inhibition of IL-2R alpha are the twin silver bullets in the mode of action that is key to calming the cytokine storm!
Here - https://www.fda.gov/media/141132/download
Their slides for the morning presentation. Head to slides 14-24
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