Your on the money E as far as the OSA research data potentially being the rocket under the SP - more fascinating OSAS related facts for those interested
jump on the web if your interested - its there
So chronic hypoxia and related oxidative stress combine with
inflammation, local and systematic inflammation.This leads to sleep deprivation and some studies have attempted to expose the
potential biomarkers in the presence of obstructive sleep apnea syndrome (OSAS) and related morbidities.
The data from these studies might trigger the
impairment of vascular endothelial cells - which leads to their dysfunction which contributes multiple end-organ morbidities such as cardiovascular disease, metabolic dysfunction and more importantly, the impairment of neurocognitive function.Many studies have suggested that OSAS can result in systemic and
local inflammation in OSAS patients.the biomarkers are clearly indicating blood testing and or urine testing will at some point be able to provide early indication of potential onset OSAS ...
A meta-analysis focusing on OSAS and inflammation noted that compared with the control group, OSAS patients presented significantly elevated
CRP, TNF-α, IL-6, IL-8, ICAM, VCAM, and selectins levels. They found the most prominent inflammatory factors presented in OSAS include
IL-1, IL-6, and CRP. Additionally, they found that alterations in
cytokine levels were closely correlated with the age, body mass index (BMI), and apnea-hypopnea index (AHI) of the patients.
* ICAM = intercellular adhesion molecule / * VCAM = vascular cell adhesion molecule
Association of inflammation and cognitive dysfunction in OSAS patients
Because plasma samples are easily available, several studies have measured serum inflammatory biomarker levels and cognitive performance in OSAS patients to observe the association between inflammation and neurocognitive deficits.Data provided by previous studies have generally considered that the activation of inflammation in OSAS patients is a
major pathological factor associated with CVD, diabetes mellitus, and nervous system diseases such as dementia, Parkinson’s disease, Alzheimer’s disease, and epilepsy ( CVD cardio vascular disease & cerebrovascular disease as well .... )Relationship between cognitive dysfunction and OSASFindings from prospective studies of OSAS and cognitive deficits along with results from observational and experimental studies demonstrated that sleep fragmentation and hypoxemia are the two most likely risk factors for cognitive decline
So much to like moving forward - solid SP action today is also very welcome.
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Not intended as financial advice
