The science here for overwhelming efficacy is not that it must be achieved, it's to rule out the fact that sometimes you get lucky with treatments that are not effective.
There are so many confounding factors that all add together to make it unreasonable to claim it works based on small numbers - different hospitals, different standards of care, different population genetics, ........ Just look at the death rate that was used in the initial emergency use and ask yourself if that is an accurate comparison to make now...
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