Not sure if this has been answered already.
If this mob make optimisations to bisantrene do they have to start the approval process from scratch?
"Because CS1 (bisantrene) and CS2 (brequinar) have been tested in multiple clinical trials under the guises of other objectives, Chen and his colleagues believe this basic research has access to a freeway entrance that will fast track it into clinical trials. The National Institutes of Health (NIH) has already funded the next step: The Chen lab is working to further optimize CS1 and CS2 to develop improved FTO inhibitor compounds that are more efficacious with minimal side effects for humans."
"The lab began working on the CS1 and CS2 project three years ago (~Mid 2017) when Chen first arrived at City of Hope."
Is any of this work published? could it be helpful to design our FTO trial?
A group of researchers independently looking at bisantrene for 3 years and were interested for a different reason than RACE, originally.
What a gift.
https://www.cityofhope.org/news/powerful-small-molecules-may-be-able-to-kill-cancers
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