I would be very interested to know what the all cause mortality rate was in either groups.
According to data I've seen, 3 year survival for NYHA class 2 patients is roughly 70-80%.
As they measure at 30 months you would assume their survival in the control group would be towards the higher end of that range.
Now with say, a 25% mortality rate in a subgroup of 103 patients (206 with an assumed 50/50 control), that would be say 27 people died in the control group.
For a 60% reduction in mortality, that's roughly a difference of 10 people, right?
For a mortality difference of 10 patients in cohorts of 103 per arm I don't see how they got a significance of <0.037.
I haven't plugged it into an equation, but that seems like a very small difference in an N that isn't extremely large.
I know there are some stats experts in here, I'd love to be corrected.
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