Australia's largest stock trading and investment forum Australia's #1 stock forum

MSB

Click for more information

1.51%

98.0¢ mesoblast limited

Ann: Rexlemestrocel Reduces Heart Attacks/Strokes/CV Death in CHF, page-379

First 379 Last

Share
Profile

Follow
Gan_Gans

2,132 Posts.

570

12/01/21

14:20

Post #: 50112651
Share

Originally posted by Davisite: ↑

Unfortunately not. Here is a copy of my post on the 15/12

This section for the FDA Guidance on Multiple Endpoints is worth considering and lamenting.

There have been situations, however, where the effect on the primary endpoint was not found to be statistically significant, but there did appear to be an effect on mortality or major morbidity. In the absence of a demonstrated treatment effect on the primary endpoint, secondary endpoints cannot be assessed statistically, but the suggestion of a favorable result on a major outcome such as mortality may be difficult to ignore.

One approach to avoid this situation would be to designate the mortality or morbidity endpoint as another primary endpoint, and apply one of the statistical methods of section IV with unequal splitting of the alpha. In this way, the endpoint can be validly tested, and should the effect be large, it will provide evidence of efficacy. Depending upon how alpha is allocated, the increase in sample size to maintain study power may only be modest.

Expand

May I ask......in the presentation and the graphs on page 23 & 25 - what are the numbers against the timepoints in red and blue on the x axis?

MSB Price at posting: $2.63 Sentiment: Sell Disclosure: Not Held
Upvote

0 Great analysis

Reply

Top Stories

IIQ

INOVIQ says it has found a way to test blood for Parkinson's Disease – after Alzheimer's success in June

SGQ

St George Mining jumps 8% on news it's appointed two niobium executives – from the world's biggest player, CBMM

WAF

West African snaffles gold intercept at 7.3 g/t in Burkina Faso

VCX

Vicinity buys a half share in Lakeside Joondalup Shopping Centre for $420M

CC9

Chariot locks in high-potential drill target at Black Mountain, one of the USA's largest lithium landholdings

There are more pages in this discussion • 385 more messages in this thread...

First 379 Last

Add MSB (ASX) to my watchlist

(20min delay)
Last 98.0¢		Change -0.015(1.51%)		Mkt cap ! $1.124B

Open	High	Low	Value	Volume
$1.00	$1.01	97.5¢	$713.1K	723.1K

Buyers (Bids)

No.	Vol.	Price($)
12	87732	97.5¢

Sellers (Offers)

Price($)	Vol.	No.
98.0¢	16911	5

View Market Depth

No.	Vol.	Price($)
8	74853	0.975
15	201572	0.970
12	135230	0.965
12	134707	0.960
4	117484	0.955

Price($)	Vol.	No.
0.980	46302	36
0.985	25460	10
0.990	68822	32
0.995	77668	5
1.000	92548	8

Last trade - 11.55am 20/08/2024 (20 minute delay)

MSB (ASX) Chart