Ann: Consistent pain reduction and improvement in function data, page-75

Hi Leigh,
Par started off by using Koos as it a larger broader set of questions but the FDA tend to use Womac scaling.

This primarily involves three separate sections

1. PAIN
2. STIFFNESS
3. PHYSICAL FUNCTION

Of these sections we are concentrating on Pain and Function.

From what I know the scaling as you infer has five levels, namely

0 None
1 Mild
2 Moderate
3 Severe
4 Extreme


We have begun switching to this (SAS and EAP as examples) to align our data going forward.

This I believe will be used in P3 and ongoing studies ...

So perhaps to anticipate your next question, whats the difference between the two? I've heard that Koos is more weighted towards the younger patient and attempts to pick up readings and data from a more active person. As we know OA can no longer be deemed to be purely an older person's disease. many middle age and younger folk develop it, the stats for how many kids/teenagers develop it is also concerning.


Hope that helps