Given that the upcoming DIPG combination trial will use 2 drugs, one which blocks the glucose utilization pathway (paxalisib) and one which blocks the oxidative pathway (IIRC), I think it would be worth it to try paxalisib in combination with Cantrixil to see what happens, as Cantrixil also seems to affect the oxidative pathway (thereby blocking the 2 major pathways for excessive metabolism in cancer cells).
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