CLTX-CAR T is a game changer, page-8

License is for the global rights to develop and commercialise certain patents relating to CLTX-CAR T cells, that is those relating to GBM, as well as other cancers. So my understanding is that it is for the CLTX CAR T platform for solid cancers, but City of Hope may also hold other CLTX-CAR T patents relating to other conditions outside of solid caners, which does not appear to be under this license.

CLTX has been shown to bind extremely well to many solid cancers, and they believe it is targeting the MMP-2 receptor which are highly expressed in solid cancers in which CLTX appears to be able to bind. I know they are looking at melanoma right now and I'd expect some preclinical studies to commence in 2021 for this indication.

City of hope license to Chimeric

So if they want to swap out CLTX for something else, I believe that would be a totally different technology / license. But from what I've read, CLTX is by far the most promising technology coming out of City of Hope when it comes to potentially treating solid cancers, which is why it was licensed out by Chimeric and listed on the ASX.

So if we get a good read-out in the phase I trial, then the MOA proof of concept against GBM will open many doors to other solid cancers which show a high chance of success i.e. solid cancers with a high MMP-2 expression.

RAC is a little further down the track as the technology they acquired has decades of track record which they can build on. However CHM is actually ahead of RAC if we were looking at the FTO market that RAC is chasing now (still in preclinical) and comparing that to where CHM are with the CLTX CAR T which is already in phase 1 trials.

So if the researchers at City of Hope are right, then I can see CHM easily surpassing RAC in the next 12 months especially if it shows that it is able to tackle GBM which is the mother of all solid cancers. Whilst the use of CLTX is novel in a CAR T setting, the use of CLTX as an imaging agent is clearly established and can be used to expand the CLTX CAR T pipeline very rapidly.

But for now CHM is very much flying under the radar and once it gets the same attention as RAC or IMU.. these prices will be long gone.