Ann: Second independent study shows Bisantrene inhibits FTO, page-50

Quite high numbers coming from a review in 2015 evaluating incidence of cancer and cardiovascular disease cases from only dietary arsenic. Considering water and environmental contamination play a role, this figure would be higher.


https://www.sciencedirect.com/science/article/pii/S0013935119300210?via%3Dihub

Key point is that Bisantrene was shown to be effective in a cancer mouse model that overexpresses FTO.

@RaceOncology I am wondering what your thoughts are on the xenograft transplantation in these mouse models. From what I have read, there are limitations in extrapolating mouse model findings to humans because transplantation site does not reflect host microenvironment. However, since the xenograft transplant in this model is a skin tumor and has been injected subcutaneously into the mice, I am thinking that there may be some similarities between the microenvironment and hence can be confident in the findings observed. Wondering if you have any commentary on that.