Yes. I have not done enough reading to speak clearly on the in-human evidence supporting the safety of 4-HPR. I've been distracted by other things, as I'm sure you're aware. From memory, the dose used in animal model studies is tolerable in humans, but I would need to read back over it.
There are more recent preclinical activities that have been initiated since 2014.
2017: https://pubmed.ncbi.nlm.nih.gov/28988109/
2015: https://pubmed.ncbi.nlm.nih.gov/25313218/
2017: https://pubmed.ncbi.nlm.nih.gov/29051080/
Looks to be a very interesting opportunity.
ISLAND PHARMACEUTICALS LIMITED ILA IPO Analysis, page-70
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