On the topic of cardiotoxicity, came across this from the national breast cancer foundation that it is indeed common from current treatment. Also, the use of exercise, and nutrition is known to be able to down-regulate FTO to some degree which this study is targeting. Bisantrene in combination with the immunotherapies will hopefully work here.
"Cardiovascular disease is a potential complication of breast cancer treatment and is the second-leading cause of death following a breast cancer diagnosis (after cancer itself). In older women, after 10 years from diagnosis of cancer, the number of deaths from cardiovascular disease exceed those from cancer. "
https://nbcf.org.au/project/reducing-the-burden-of-cardiovascular-disease-from-breast-cancer/
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-020-00489-1
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