re: 4. preliminary final report. 4
http://stocknessmonster.com/news-item?S=PBT&E=ASX&N=223248
Extract:
Drug Development:
" PBT-1: Double blind proof-of-concept clinical trial and extension clinical trial complete. Results of the
initial double blind portion of the study were submitted and published in the prestigious specialist journal
Archives of Neurology in December 2003.
· PBT-2: Proprietary lead molecule selected and formal development initiated. Formal toxicology is
targeted to complete in 2004 and if successful this will allow clinical trials to initiate in early 2005
· Design and synthesis is underway for next generation compounds for Alzheimer ’s disease (NG-1) and
Parkinson’s Disease (NG-2). Multiple candidates for NG-1 have been identified and a development
candidate is targeted in 2004.
· Immunotherapy: Research progressing and on track for initial proof of principle trials to initiate in 2004.
· Chemistry and Discovery program: Over 400 MPACs (metal-protein attenuating compounds) now
designed, synthesised and tested in preclinical models.
Over 100 MPACs of new structural classes from
PBT-1 and PBT-2 synthesised and tested".
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