Australia's largest stock trading and investment forum Australia's #1 stock forum

RAC

1.74%

$1.47 race oncology ltd

Pillar 1 - FTO (new thread), page-1494

First 1494 Last

Share
Profile

Follow
IndexInvestor

8,645 Posts.

1427

09/09/21

04:57

Post #: 55936201
Share

Originally posted by shyaam1996: ↑

Hi II,

I actually haven’t - I’ve seen a number of a papers citing METTL3, METTL14 and WTAP upregulation or downregulation being present in various cancers, however none of them I’ve seen discuss in development of targetted drugs from these methylators.

Interestingly I came across a study showing that METTL3 was upregulated in AML cells:

https://www.researchgate.net/publication/326556665_METTL3_regulates_WTAP_protein_homeostasis

From what I understood, the study demonstrated that over expression of METTL3 positively resulted in an increase of WTAP. The study then goes on to suggest this ‘abberant’ WTAP expression may likely be the link to AML in this case.

Another study (below) seems to suggest that METTL3 also suppresses a tumor suppressant gene known as Adenomatous Polyposis Coli (APC) - this was observed in
esophageal cancer cells (ESCC).

https://www.nature.com/articles/s41467-021-23501-5

Mason is definitely correct in that there a myriad of different cancers that link to dysregulation of the methylase/demethylase pathways.

Expand

Gao, Double Edged Sword, 2021.pdf

This article from July 2021 is a good summary of the complexity.
It cites Su el al, 2020 (Reference 105)

But July 2021 is old.

Apologies if you already found this one.

RAC Price at posting: $3.40 Sentiment: Buy Disclosure: Held
5 Upvote

0 Great analysis

Reply

Top Stories

'We're looking': Nickel-rich Indonesia sounds graphite warning to Aus producers

Bitcoin hits fresh record as instos pile into BTC ETFs – and Trump helps, too

Making money: How many microcaps should be in an investor's portfolio?

MKT

The ASX can overlook its Telecomm small-caps. Here’s one diversified brand with an international footprint

MIN

Movers and Shakers: Zip Co, MinRes, Kuniko, more – The week's top ASX gainers

The Altcoin Landscape (Part 1): Key alternative cryptocurrencies to watch

Week 44 Wrap: Relatively boring week ahead of US election; HotCopper's most watched; Oz inflation at 3.5%

DXB

Dimerix links up with US NEPTUNE network to boost recruitment for FSGS study

Palladium's the newest geopolitical hot commodity. But ASX exposure is limited

Aussie inflation seemingly hit a 3 year low. So why's the ASX200 red?

There are more pages in this discussion • 1,538 more messages in this thread...

First 1494 Last

Add RAC (ASX) to my watchlist

(20min delay)
Last $1.47		Change 0.025(1.74%)		Mkt cap ! $249.7M

Open	High	Low	Value	Volume
$1.44	$1.48	$1.44	$25.63K	17.46K

Buyers (Bids)

No.	Vol.	Price($)
1	312	$1.47

Sellers (Offers)

Price($)	Vol.	No.
$1.48	354	1

View Market Depth

No.	Vol.	Price($)
1	312	1.465
2	2880	1.460
1	8653	1.450
1	548	1.440
1	2046	1.420

Price($)	Vol.	No.
1.475	354	1
1.480	11014	1
1.495	2500	1
1.500	4999	1
1.520	485	1

Last trade - 16.10pm 01/11/2024 (20 minute delay)

RAC (ASX) Chart

Pillar 1 - FTO (new thread), page-1494

'We're looking': Nickel-rich Indonesia sounds graphite warning to Aus producers

Bitcoin hits fresh record as instos pile into BTC ETFs – and Trump helps, too

Making money: How many microcaps should be in an investor's portfolio?

The ASX can overlook its Telecomm small-caps. Here’s one diversified brand with an international footprint

Movers and Shakers: Zip Co, MinRes, Kuniko, more – The week's top ASX gainers

The Altcoin Landscape (Part 1): Key alternative cryptocurrencies to watch

Week 44 Wrap: Relatively boring week ahead of US election; HotCopper's most watched; Oz inflation at 3.5%

Dimerix links up with US NEPTUNE network to boost recruitment for FSGS study

Palladium's the newest geopolitical hot commodity. But ASX exposure is limited

Aussie inflation seemingly hit a 3 year low. So why's the ASX200 red?

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News

Pillar 1 - FTO (new thread), page-1494

Top Stories

'We're looking': Nickel-rich Indonesia sounds graphite warning to Aus producers

Bitcoin hits fresh record as instos pile into BTC ETFs – and Trump helps, too

Making money: How many microcaps should be in an investor's portfolio?

The ASX can overlook its Telecomm small-caps. Here’s one diversified brand with an international footprint

Movers and Shakers: Zip Co, MinRes, Kuniko, more – The week's top ASX gainers

The Altcoin Landscape (Part 1): Key alternative cryptocurrencies to watch

Week 44 Wrap: Relatively boring week ahead of US election; HotCopper's most watched; Oz inflation at 3.5%

Dimerix links up with US NEPTUNE network to boost recruitment for FSGS study

Palladium's the newest geopolitical hot commodity. But ASX exposure is limited

Aussie inflation seemingly hit a 3 year low. So why's the ASX200 red?

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News