I had a bit of a "a ha" moment the other day when I heard these comments from Dr Triebel (from the webinar) explaining why efti has shown responses in both hot and cold tumours, whereas a conventional blocking antibody (e.g. relatlimab) is less likely to be effective in cold tumours.
As in - you can't block LAG-3 on a T cell in a cold tumour - because the T cells are not present:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376112/
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cold-tumor
For me, it was an important insight.
Cytlimic, peptide vaccines and Imugene, page-3
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