We have no more data other than this (a bit clinical), published in 2018.
https://www.raceoncology.com/wp-content/uploads/2020/08/PBC-060818-Bisantrene-Combo-Poster.pdf
This is the abstract:
https://www.omicsonline.org/conference-proceedings/2161-0681-C1-046-001.pdf
Recognising that AML is one of the hardest to treat cancers, 5 of the 7 patients in the last study (Spaedea et al 1993) achieved Complete (within 15 to 54 days of treatment) and two of these had no progression (relapse) of disease at 42+ and 46+ months respectively.
Extract below from: Spadea A, et al. Leuk Lymphoma 1993;9:217-220
This was a single-agent trial:
I speculate a key reason for the number of CRs achieved was the application of the consolidation course. It could also be that the 2 patients that achieved 42+ and 46+ months progression free may have coincidentally over expressed FTO (but this is just speculation).
The paper doesn't give any information about any follow-up bone marrow transplants the patients received.
For some context we have the extract below from:
https://www.cancer.net/cancer-types/leukemia-acute-myeloid-aml/statistics
The 5-year survival rate tells you what percent of people live at least 5 years after the cancer is found. Percent means how many out of 100. The 5-year survival rate for people 20 and older with AML is 27%. For people younger than 20, the survival rate is 69%.
So RACE have in their hands an asset with some compelling historic complete response rates for a deadly cancer, including as a single-agent. Complete Response = no detectable cancer.
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