Antibody response in HIV-infected individuals tends to have half the antibody response to vaccines compared with other groups. The only other group which is is lower is organ transplant recipients who are on a range of anti-rejection drugs. You don't need to find all the same people for a study, just get a baseline and then daily antibodies and symptom score sheet. Those that are vaccinated will have perhaps higher IGg to start with but around 30% of HIV infected (vs 5% general population) individuals lose their IGg within 3 months of infection or vaccination. source. I still feel that with around .5 of the average population likely to contract or be exposed to COVID19 during six months we shall see some interesting data. It is said that immuno-compromised people have three times more chance of contracting severe COVID19 symptoms when exposed. So it is likely we do see some interesting data. This is all irrespective of ART-naive or not and is probably more related to individual CD4 levels. It will be difficult to put this into context in the study but not impossible.
We have a small study, yes, but we have no money and yet to spike interest from big money. This is a favourable step in the direction we want to take.
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