Hi Zenox
I noticed you were not expecting any change in the cartilage degrading products such as COMP and ADAMTS-5 in the synovium at Day 56 from baseline - suggesting these could take longer.
Can I ask, is this specifically due to the fact the readings are from the synovium? The Phase 2b results showed a material reduction in both of these markers at Day 53 in the serum samples from that trial.
Ann: Successful MPSVI Safety Review and PARA OA 008 Update, page-79
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