Ann: Appendix 4E & Annual Report 2022, page-11

IMINVESTOR101....Would you kindly explain why you feel there is only a 15-20% chance of success with ATH434? I totally disagree with that belief if only because of the focus, determination and effort that Alterity has put forth thus far and promises for the future with ATH434. Until now, they have been very careful to do everything in their power to "dot their i's and cross their t's" and are committed to following this through to a positive and successful conclusion...So far...So good. I also believe this explains why they seldom mention what may be going on with PBT2, which I'm sure they are thrilled about, but purposely do not divulge the status of the extremely complicated process of getting that wonder drug to market.