General Comments / Chat, page-6097

All things point in that direction

#Zantrene (Disruptive Epigenetic Platform Therapy)
[First in class - Best in class - FTO inhibitor]

FTO Commercial Potential


Source: Investor-Presentation-November-2021.pdf (raceoncology.com)

Cancers overexpressing FTO (29+ cancers)

Source: www.raceoncology.com.au

FTO Pathways that may aid in overcoming resistance.


Source: IJMS | Free Full-Text | FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms | HTML (mdpi.com)

Standard of Care (FTO Upregulation)

Sample treatments that upregulate FTO, which may benefit from FTO inhibition due to acquire resistance.

Dacogen (Decitabine) - Upregulate FTO


Source: Targeting FTO suppresses cancer stem cell maintenance and immune evasion - PMC (nih.gov)

Bortezomib (Bort) - Upregulate FTO
Source: FTO promoted MM progression and Bort resistance A and B qRT-PCR and... | Download Scientific Diagram (researchgate.net)

Radio Therapy - Upregulate FTO


Source: m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis - ScienceDirect

Not an opinion, DYOR and read the source documents for context.