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I think we each should search within for the tranquility of patience. This may take a while yet.
Given that what was a funny sounding chemical in a test tube 4 years ago, is now a largely de-risked candidate as a product of commercial and medical significance, the (commercial) value of which should materialise this year is grounds for holding a certain serenity.
The biggest risk I see for myself as a long-term holder is my own impatience.
Of course I want to see FDA approval and commercialisation next week! oh give me strength - next month!, but wanting it ain't gunna make it so.

And if I can throw in a personal note, I happen to be in a tighter spot financially these last months than I have been for some years, so if you've got any tranquility pills to spare, I may need them yet!

OoohhhhhhmmmmmmmmmmmmmanipadmeOooohhhhhhhhhhhhmmmmmmmmm.

(gazes at navel - are we there yet? Nix ! )

OoohhhhhhmmmmmmmmmmmmmanipadmeOooohhhhhhhhhhhhmmmmmmmmm.

(repeat ...)