MSB 2023 - awaiting for Ryoncil approval, page-135

The CRL Dachopper refers to "around the time of the CRL" came out from memory on the 1st of October 2020 - about a month and a half after the 13th of August 2020 ODAC meeting.

I recall SI speaking at ODAC about other potential potency assays under a TNFR1 umbrella being able to be produced in future and about limitations in IL2Ralpa but I didn't hear him speak about another potency assay other than that.

Do you? Because the post of Dachopper's you are responding to in praise of is a recollection of his that he isn't providing a source for.

I can't think of any reason why SI would not have said MSB had adopted INF-gamma as part of their potency testing in a company announcement if they had and I do recall quite a few company announcements where the language strongly suggested no potency assays other than those already used - but optimised ones already used - were being used.

The whole timeline of what has been said (Dr Rose speaking about reverting to a previous assay and there being problems with it was much more recent than just after the CRL and would not make sense if INF-gamma was being introduced as alternative - it wouldn't be reverting - it wasn;t previously used.).

Dachopper has some good points. But I think he is mistaken in suggesting a) INF-gamma has been added (and that SI said so as long ago as around the time of the CRL) and b) that it would make any sense, serve any purpose to try to keep the use of INF-gamma a trade secret if MSB did add it as a potency assay and c) that bringing it in late after clinical trials that didn't use it as a potency assay had been done and didn't use it wouldn't be problematic.

If you can, as a holder recall SI saying the same thing Dachopper says he recalls then chances are better that SI actually did say that in my opinion and that Dachopper isn't just mistaken.

But if he said it in a webinar or an AGM (which I might have missed) he'd probably repeat it in a response to an email or a question and I think he also would have put it in a company annoucement like a quarterly update or something as well.