Ann: FDA approves Daybue - the first treatment for Rett syndrome, page-56

I have three concerns weighing on my mind at moment, none of which may have any foundation. I will be interested in other people's thoughts:

1. what if Avonex gets approved as a rival treatment for Retts in the next year or two? Will this mean that Acadia's sales of Daybue get seriously eroded into?

2. what if Daybue is priced much lower that we expect, because the US insurance companies refused to agree to pay the high price that we expect?

3. what if a sizeable portion of the small number of Rett families are not covered by medical insurance reimbursement? Perhaps when a couple has a child with serious special needs, one of the couple is more likely not to work in order to care for the child? Would a family on just one income be able to afford the out-of-pocket expenses of a partly-reimbursed drug?

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when will pricing of a newly approved drug likely to be announced? Does it take a few weeks or months, while the various health insurance companies thrash it out with Acadia?