Ann: Capital Raising Presentation, page-201

Okay, I've come back to here from your other post. I've a hard copy of the study you referred to.

"Its a retrospective observational cohort study." Basically the went back through hospital records. "Of 140 adult patients, with a plantar DFU". The word planatar is important here because that refers to the tissue on the sole of the foot from the heal forward to where the toes are. They were only interested in plantar DFU wounds, not wounds between toes and not wounds on the side of the lower leg. Both the photos we have seen from CYPs DFU study would not have qualified for thus study as the wounds were in the wrong places.

A wound on the bottom of the foot is different - you potentially need to stand on you foot to move around - its weight bearing - not so the side of your foot, nor even so much between your toes.

This paper based retrospective looking study was done in Canada looking at patient documents from Jan 2012 until December 2018. Nearly 7 years. And it was written up in 2020.

Page 10 near the bottom left "Finally our study examined patients with DFU located only on the plantar aspect of the foot. Therefore, results cannot be generalised to patients with interdigital or dorsal DFU. (Dorsal would be the top of the foot - what you see standing looking down on your own foot).

The whole "41.8% wound size reduction at 4 weeks was identified as the best cut-off value, and was associated with an AUC of 0.86 " etc etc - comes from page 6 of the paper - the only part of the paper that refers to Figure 2 which is entitled ROC curve analysis for wound area reduction at 4 weeks and wound healing at 3 months".

To my eyes the authors do not really explain their method properly - they do have references to about 5 other papers and if this paper looked like a good and relevant primer for what you and I should be interested in I'd be happy to go into those references but to me they don't and this doesn't. The papers go back to 2003, 2003, 2009 , 2001 and 2010 respectively and seem to bear out in part why these authors are interested in 4 weeks in particular.

But Truss20 what I was offering to do was to read a paper you could provide if you had one that was relevant to the question how is diabetes foot wounds different to other types of foot wounds like say wounds arising from burns. I meant in terms of what is going on with the cells and the healing environments in the foot and in the wounds on the foot.

This article that you've referenced isn't a very good match for what CYP is doing - wrong places on the foot. Is a paper based study. Something like a modern review article would be better - I could find one I believe - but the point for me was it if you found it you'd have some input in deciding why you picked it.

For me, right now, analysing the thesis is more interesting. But a review paper on DFU if you had one would be something that could be evaluated pretty quickly.