It's a pass from me...
Part immunosuppressant...
Intra articular and a couple of warnings:
"Serious and sometimes fatal infections may occur during treatment with canakinumab. Call your doctor right away if you have signs of infection such as: fever, chills, sweating, tiredness, cough, shortness of breath, skin sores, warm or painful areas on your body, diarrhea, stomach pain, or weight loss".1
"Canakinumab can weaken your immune system. Your blood may need to be tested often". 1
(My emphasis added below)
"Innate immunity drives atherogenesis and cardiovascular risk, but also participates in host defenses against pathogens. The Canakinumab Anti-Inflammatory Thrombosis Outcomes Trial (CANTOS) showed that treatment with the anti-interleukin-1β antibody canakinumab improved cardiovascular outcomes, but associated with a small increase in fatal infections".2
Not saying it doesn't have a place (?)..but I know what I'd wait for and which drug I'd be trying out first...
DYOR
REF
1) https://www.drugs.com/mtm/canakinumab.html#:~:text=Warnings-,Serious%20and%20sometimes%20fatal%20infections%20may%20occur%20during%20treatment%20with,stomach%20pain%2C%20or%20weight%20loss.
2) https://academic.oup.com/eurheartj/article/39/suppl_1/ehy564.358/5080115
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