The homeostasis of insulin-like growth factor-1 (IGF-1) is essential for metabolism, development and survival. Insufficient IGF-1 is associated with poor recovery from wounds whereas excessive IGF-1 contributes to growth of tumours. We have shown that cyclic glycine-proline (cGP), a metabolite of IGF-1, can normalise IGF-1 function by showing its efficacy in improving the recovery from ischemic brain injury in rats and inhibiting the growth of lymphomic tumours in mice. Further investigation in cell culture suggested that cGP promoted the activity of IGF-1 when it was insufficient, but inhibited the activity of IGF-1 when it was excessive…..
Our data suggest that cGP is an additional component in the axis regulating IGF-1 homeostasis and that cGP has potential therapeutic applications for a long list of medical conditions where IGF-1 homeostasis is impaired.
(cGP = NNZ-2591)
https://www.nature.com/articles/srep04388
Also worth reading on this subject
IGF-1: The Jekyll & Hyde of the aging brain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988994/
Psychiatric Indications, page-10
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