My understanding is that there are multiple pathways anthracyclines target that produce cardiotoxicity, from mitochondrial direct to indirect. We really need to know what the cardio MoA for Bisantrene is so that our targets can be a little more real. If Bis MoA was targeting a similar pathway in Ara-C, that would be a very big de-risking event for the upcoming trial. Probably already the most derisked oncology drug on the planet.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080657/pdf/fcvm-07-00035.pdf
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