PAA 4.88% 21.5¢ pharmaust limited

Ann: PharmAust receives Orphan Drug Designation for monepantel, page-43

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  1. 2,347 Posts.
    lightbulb Created with Sketch. 2935
    Given the discussions above on Biogen's decision and neurofilament biomarkers, this comment jumped out at me in this article :

    https://endpts.com/biogen-and-ionis-abandon-als-drug-after-disappointing-early-stage-trial/

    https://hotcopper.com.au/data/attachments/6181/6181172-8f23545862415db3e470c290ad88e72d.jpg


    That's pretty big news for PAA and MPL.
    Frontotemporal degeneration stands out as a very adjacent indication to MND/ALS , and if MPL is proven efficacious against MND ( including +ve results in NfL's ) , odds on it would also prove efficacious against FTD - and neurofilament markers would qualify as a validated endpoint in clinical studies.


    Last edited by Quiltman: 18/05/24
 
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