Although a recent article published in Immunology & Cell Biology (see link below) will not give you an answer to your question about the FDA's current fascination with IL-2R, it will likely give you and others here an insight as to how the soluble factor currently known as IL-2R was recognised over 40 years ago as having a vital role to play in the mammalian immune response to foreign immunogens. Most of the research described in the article was carried out at the ANU's John Curtin School of Medical Research by Kevin Lafferty's group, of which I was fortunate to be a member around that time. It's my believe that Kevin Lafferty was deserving of a Nobel Prize for his work, although at the time immunological research in Australian was ground-breaking in a number of ways, and I consider that there were several Australian-based immunologists worthy of the honour back then.
Ref: Immunology & Cell Biology 2023; 101: 678–683
https://onlinelibrary.wiley.com/doi/pdf/10.1111/imcb.12683
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