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clock Created with Sketch. 19/03/25
19:38
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Originally posted by MongooseMan:
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tell me, have you prescribed Filspari, or have you spoken to proper doctors that have prescribed filspari? I can tell you we have, nephrologists using filspari currently in IgA nephropathy or during clinical trials, and none expressed any big concern about the FDA imposed warnings. Some of this wording imposed by FDA is a legacy of earlier endothelin blockers. We were told the liver monitoring is not a major issue because these patients are having regular blood tests anyway as part of their kidney disease management and they are used to dealing with drugs which show liver enzyme changes. Anyway it looks like some of this is going to be relaxed by FDA. This isn't the first drug to have warnings about usage in pregnancy. The DXB phase 3 trial excludes pregnant women, is that because there is a risk picked up in animal studies that will also end up with a warning?
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dude you making way too many assumptions on what might happen…
(20min delay)