@ttppxx - I’d be interested to hear your thoughts on the below on how it might relate to making Clarity’s Bis technology obsolete? One would think that if we could imagine/treat multiple targets in one sitting (both known now and newly discovered in future) we could potentially have 2,3,4 targets light up in the same tumour.
In lesion-based analysis, [68Ga]Ga-RM26 PET/CT had sensitivity and specificity of 0.38 and 0.99, respectively, compared with 0.5 and 0.99 for [68Ga]Ga-PSMA-617 PET/CT. [68Ga]Ga-RM26 PET/CT identified 41.4% (12/29) of pathologic positive nodes missed by [68Ga]Ga-PSMA-617 PET/CT.The combined [68Ga]Ga-RM26 and [68Ga]Ga-PSMA-617 PET/CT demonstrated sensitivity of 0.71 and specificity of 0.99. Conclusion: In dual-target imaging, [68Ga]Ga-RM26 PET/CT identified additional PLNMs. The combination of [68Ga]Ga-RM26 PET/CT and [68Ga]Ga-PSMA-617 PET/CT achieved higher diagnostic sensitivity with minimal loss of specificity.
https://jnm.snmjournals.org/content/early/2025/03/19/jnumed.124.269189
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