Ann: NNZ2566 Rationale in ASDs , page-4

Looks like there's another subtle link again with the work we are doing with Dr. Eric Hollander.

Here's the presentation that Eric did a little over a year ago (see underlined below)...

http://www.autismus-kongress.de/media/Vortraege_2012Praesentation_Autismus2012_Hollander.pdf

Cell cycle – synapseopathy; dendritic sprouting; macrocephaly
uPTEN, IGF-1, NNZ-2566 (ACE, Simons), oxytocin
M-TOR – rapamycin, afinitor

and

These effects may be mediated by modulation of the PI3K-Akt-mToR pathway.

and here is NEU's CA today.... that's the pathway Eric is referring to...

IGF-1 and Glypromate is a natural growth factor that:
o May act via the Akt-mToR pathway

and

Model for how serotonin and PI3K signaling
pathways interact via SLca4 and Pten to influence
brain size, sociability, PPI, perseverative
behaviors (Page et al, 10.1073/pnas.0804428106)

Here's a link to Dr. Eric Hollander and Dr. Mike Snape bio's....

2012 International Autism Conference Speakers

Regards,
Tony