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Bio-Layer of Queensland, Australia, has received US Patent No. 8,273,403, "Generation of surface coating diversity." The patent describes a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon that consists of three elements: a chemical backbone coating on the solid substrate that comprises a copolymer of a passive constituent and an active constituent; a spacer unit separating the backbone from a functional group; and a functional group.