just for the informational purposes wanted to mention that an idea of treating HepC with siRNA (or ddRNAi, smae concept, different mechanism of delivery) is old and being brushed away by the leaders in this filed, such as ISIS Pharmaceuticals.
Here is the link on Phase I data from ISIS
http://www.ncbi.nlm.nih.gov/pubmed/16274834
CONCLUSIONS: ISIS 14803 treatment was associated with HCV reductions in only 3/28 patients. This is due to significant IRES genetic evolution in the virus, making "the drug" (RNAi construct) useless.
To be fair, Benitec has two more RNAi elements in their construct, both targeting NS5B. But the fact that Gilead's Sofosbuvir (a leading HepC product on the market) targets the same target by a different mechanism and has cure rates of 90%+.... makes Benitec proposition very questionable.
In addition, Gilead's drug is an oral pill and not an injection like BLT's offer.
old myth of curing hepc with antisense
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