... so sorry, page-27

R.E. placebo decreasing: I'm not sure that the decline was statistically significant (no raw data released). If not, the decline is likely due to chance. I think the most likely explanation is that PiB PET has fairly significant variability in interpretation, and therefore their amyloid didn't decline, but the PET said it did (incorrectly so). The trial was also prone to this due to the small sample size and use of PiB PET (if sample size was much larger, probably wouldn't have happened). I understand that the treated group, given was twice as large, did show statistically significant decline in amyloid.

I disagree with TL earlier post r.e. every trial has a placebo effect and that therefore a placebo should reduce insoluble plaque - see other studies in this field where plaque is not decreased in the untreated.